Protein Details: Calcium-activated chloride channel regulator 1
Protein ID
ICDB_Pro_0608
Protein Name
Calcium-activated chloride channel regulator 1
Gene Name
Organism
Bos taurus (Bovine)
Length
903 amino acids
AlphaFoldDB
AF-P54281-F1-model_v4.pdb
Function
May be involved in mediating calcium-activated chloride conductance . May play critical roles in goblet cell metaplasia; mucus hypersecretion; cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Sequence
MVPRLTVILFLTLHLLPGMKSSMVNLINNGYDGIVIAINPSVPEDEKLIQNIKEMVTEASTYLFHATKRRVYFRNVSILIPMTWKSKSEYLMPKQESYDQAEVIVANPYLKHGDDPYTLQYGRCGEKGQYIHFTPNFLLTNNLPIYGSRGRAFVHEWAHLRWGIFDEYNGDQPFYISRRNTIEATRCSTHITGTNVIVKCQGGSCITRPCRRDSQTGLYEAKCTFIPEKSQTARESIMFMQSLHSVTEFCTEKTHNVEAPNLQNKMCNGKSTWDVIMNSTDFQNTSPMTEMNPPTQPTFSLLKSKQRVVCLVLDKSGSMSSEDRLFRMNQAAELFLIQIIEKGSLVGMVTFDSVAEIRNNLTKITDDNVYENITANLPQEANGGTSICRGLKAGFQAIIQSQQSTSGSEIILLTDGEDNEIHSCIEEVKQSGVIIHTIALGPSAAKELETLSDMTGGHRFYANKDINGLTNAFSRISSRSGSITQQTIQLESKALAITEKKWVNGTVPVDSTIGNDTFFVVTWTIKKPEILLQDPKGKKYKTSDFKEDKLNIHSARLRIPGIAETGTWTYSLLNNHASPQILTVTVTTRARSPTTPPVTATAHMSQNTAHYPSPVIVYAQVSQGFLPVLGINVTAIIETEDGHQVTLELWDNGAGADTVKNDGIYSRYFTDYRGNGRYSLKVHAEARNNTARLSLRQPQNKALYIPGYIENGKIILNPPRPEVKDDLAKAEIEDFSRLTSGGSFTVSGAPPGNHPSVLPPNKIIDLEAKFKEDHIQLSWTAPANVLDKGKANSYIIRISKSFLDLQKDFDNATLVNTSSLKPKEAGSDENFEFKPEPFRIENGTNFYIAVQAINEANLTSEVSNIAQAIKFIPMPEDSVPALGTKISAINLAIFALAMILSIV
PDB Structures
Ligand Binding
Binding Site
BINDING 155; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 159; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 166; /ligand="Zn(2+)"; /ligand_note="catalytic";
Disease
Location
Trachea
DOI ID
10.1074/jbc.270.52.31016
RefSeq
NP_001229512.1